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Regulatory & evidence

Regulatory applications and evidence-building from functional claims to additives and labeling.

Major regulatory filings we handle

JP

Foods with Function Claims

Systematic reviews or human trials on the final product. End-to-end support from active ingredient, mechanism and safety to label drafting.

US

GRAS / NDI

Requirement analysis, dossier drafting and FDA liaison for GRAS (self-affirmed / notification) and NDI (New Dietary Ingredient).

EU

Novel Food / Health Claim

EU Novel Food applications and Health Claims (Art. 13.5 / 14). EFSA correspondence and evidence design.

ANZ

Australia / NZ Novel Food

FSANZ Novel Food assessments and High Level Health Claim filings.

CN

New Food Ingredients / Blue Hat

New food ingredient applications (NHC) and Health Food (Blue Hat) registrations/filings (SAMR).

KR

Korea MFDS filings

Individually recognised Health Functional Food applications and clinical protocol design.

Joint support with ORTHOMEDICO

WORSO scope

  • Country-level regulatory analysis and strategy design
  • Filing-route selection (notification / registration / prior evaluation)
  • Local authority liaison, agent and language coordination
  • Label drafts and packaging development
  • Post-filing customs and distribution coordination

ORTHOMEDICO scope

  • Human trial protocol design and execution
  • Systematic reviews
  • Safety and efficacy literature surveys
  • Statistical analysis and publication
  • Full-service CRO operations

Process steps

  1. 1

    Requirement analysis

    Review target-country schemes and required evidence; assess feasibility.

  2. 2

    Evidence strategy

    Decide whether existing literature suffices or new human trials are needed; optimise cost-effectiveness.

  3. 3

    Trials and research

    ORTHOMEDICO leads the human trials and systematic reviews.

  4. 4

    Dossier drafting

    Prepare country-specific application forms and supporting documents.

  5. 5

    Authority response

    End-to-end support for Q&A, supplementary submissions and local agent coordination.

Turn evidence into pricing power

Bridge clinical evidence to regulation, labelling, filings and distribution — and maximise product value.

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